The Efficient Total Synthesis of Bioactive Microbial Natural Products.
نویسندگان
چکیده
منابع مشابه
Total Synthesis of Bioactive Natural Products - A Personal Perspective
Total synthesis of complex molecular architectures has long been recognized as the most powerful form of training for synthetic organic chemists. This historical discipline has a rich and glorious tradition in both teaching and research, and is an indispensible component in any chemistry department and scientific institutions. Scientifically, in addition to the synthetic challenges associated w...
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The first total synthesis and development of a variety of bioactive natural products have been accomplished by using carbohydrates as a chiral source. In addition, practically useful intermediates have been created, analogs of natural products have been prepared, their structure-activity relationships studied, and the large-scale preparations of medicinally useful compounds established. The key...
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Cyclodepsipeptide natural products often display intriguing biological activities that along with their complex molecular scaffolds, makes them interesting targets for chemical synthesis. Although cyclodepsipeptides feature highly diverse chemical structures, their synthesis is often associated with similar synthetic challenges such as the establishment of a suitable macrocyclization methodolog...
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Our chemical syntheses and related scientific investigations of natural products with complex architectures and powerful biological activities are described, focusing on the very large 3 nm-long polycyclic ethers called the ciguatoxins, highly strained and labile chromoprotein antitumor antibiotics featuring nine-membered enediyne cores, and extremely potent anthelmintic macrolides called the a...
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1Laboratory of Applied Microbiology and Biotechnology, Department of Molecular Biology and Genetics, Democritus University of Thrace, 68100 Alexandroupolis, Greece 2Institute of Technology of Agricultural Products, Hellenic Agricultural Organization-DEMETER, 15310 Athens, Greece 3Department of Food and Nutritional Sciences, University of Reading, Reading RG6 6AD, UK 4School of Biomedical Scienc...
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ژورنال
عنوان ژورنال: Journal of Synthetic Organic Chemistry, Japan
سال: 2000
ISSN: 0037-9980,1883-6526
DOI: 10.5059/yukigoseikyokaishi.58.828